Managing Pain Topical PCORI Funding -- Cycle 1 2025

PCORI seeks to fund studies that address meaningful decisional dilemmas faced by patients, clinicians and members of the broader health and healthcare community when seeking and obtaining pain-related care and to improve patient-centered outcomes. Applications may propose patient-, healthcare provider- and/or systems-level CER studies addressing acute or chronic pain across the care continuum in any clinical context. Comparators may include pharmacological, nonpharmacological and/or combination therapies, as appropriate. Systems-level interventions may include patients, healthcare providers and/or care teams and various settings where care is delivered, organized, purchased or coordinated. At least one validated primary outcome must be focused on pain. Additional outcomes of interest should be well-justified and clinically meaningful, impactful and supported by stakeholder input. Secondary outcomes may focus on patient and caregiver quality of life, caregiver support and assessment of patient-centered economic and other burdens.

This funding announcement will accept applications with direct costs up to $12 million dollars and up to five years in duration. For this funding announcement, applicants may request coverage of patient care costs (including medical products, procedures and care services) for potential funding by PCORI. These costs are included as part of the overall direct cost maximum. For additional information, please see the full announcement.

PCORI encourages all investigators interested in applying to use this inquiry form to submit questions and request to speak with a PCORI program officer.