Broad Pragmatic Studies PCORI Funding -- Cycle 1 2025

This PCORI Funding Announcement (PFA) invites applications for high-quality comparative clinical effectiveness research (CER) projects.  

All applications must align the proposed research with at least one of PCORI’s National Priorities for Health described within the PFA (Increase Evidence for Existing Interventions and Emerging Innovations in Health; Accelerate Progress Toward an Integrated Learning Health System; Achieve Health Equity; or Advance the Science of Dissemination, Implementation and Health Communication). Research Project Agenda Topic Themesare also included in this funding opportunity. Applicants have the option to choose up to three Topic Themes based on how their proposed research aligns with the themes. However, aligning with a Topic Theme is not required. The National Priorities for Health and Research Project Agenda Topic Themes will assist PCORI in determining the optimal review pathway for the proposed research.